This work is licensed under a Creative Commons Attribution 4.0 International License.
Cathelicidin (135-146), Tylotoin
General Information
DCTPep ID DCTPep03732
Peptide Name Cathelicidin (135-146), Tylotoin
Sequence KCVRQNNKRVCK
Sequence Length 12
UniProt ID W0FJD1
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C59H110N24O16S2
Absent amino acids ADEFGHILMPSTWY
Theoretical pI 10.33
Acidic residues 0
Basic residues 5
Polar residues 4
Molecular weight (Average) 1475.79
Molecular weight (Monoisotopic) 1474.8
Common amino acids K
Net charge 5
Instability index (II) 65.83
Aliphatic index 48.33
Grand average of hydropathicity (GRAVY) -1.483
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.085, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30389988
Title Design of a novel cell-permeable chimeric peptide to promote wound healing
Doi Not available
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 12017
This work is licensed under a Creative Commons Attribution 4.0 International License.