This work is licensed under a Creative Commons Attribution 4.0 International License.
Ranatuerin-2PLx, R2PLx
General Information
DCTPep ID DCTPep03748
Peptide Name Ranatuerin-2PLx, R2PLx
Sequence GIMDTVKNAAKNLAGQLLDKLKCKITAC
Sequence Length 28
UniProt ID A0A3P8MS06
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H226N36O38S3
Absent amino acids EFHPRSWY
Theoretical pI 9.24
Acidic residues 2
Basic residues 5
Polar residues 8
Molecular weight (Average) 2961.59
Molecular weight (Monoisotopic) 2959.6
Common amino acids K
Net charge 3
Instability index (II) 3.78
Aliphatic index 108.21
Grand average of hydropathicity (GRAVY) 0.118
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.042, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30279210
Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells
Doi Not available
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 12184
This work is licensed under a Creative Commons Attribution 4.0 International License.