Nicomicin-1

General Information


DCTPep ID  DCTPep03753

Peptide Name   Nicomicin-1

Sequence  GFWSSVWDGAKNVGTAIIKNAKVCVYAVCVSHK

Sequence Length  33

UniProt ID  A0A3G2WH77 

PubChem CID  Not available

Origin  Animalia

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  6HN9 

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C161H249N43O43S2

Absent amino acids  ELMPQR

Theoretical pI  9.24

Acidic residues  1

Basic residues  5

Polar residues  12

Molecular weight (Average)  3539.13

Molecular weight (Monoisotopic)  3536.81

Common amino acids  V

Net charge  4

Instability index (II)  10.17

Aliphatic index  88.48

Grand average of hydropathicity (GRAVY)  0.379

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 12615
  Abs 0.1% (=1 g/l) 3.564, assuming all pairs of Cys residues form cystines
  Ext. coefficient 12490
  Abs 0.1% (=1 g/l) 3.529, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30360541

Title  Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain

Doi Not available

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  12236

DCTPep is developed by Dr.Zheng's team.