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Antimicrobial peptide 1, Cn-AMP1
General Information
DCTPep ID DCTPep03756
Peptide Name Antimicrobial peptide 1, Cn-AMP1
Sequence SVAGRAQGM
Sequence Length 9
UniProt ID P86705
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | 2.4±1.75% Cytotoxicity=100µM | MTT assay | 48h | 1 |
| HCT 116 | Colon carcinoma | 5.8±3.21% Cytotoxicity=100µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2023-11-02
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C34H61N13O12S1
Absent amino acids CDEFHIKLNPTWY
Theoretical pI 9.47
Acidic residues 0
Basic residues 1
Polar residues 3
Molecular weight (Average) 876
Molecular weight (Monoisotopic) 875.43
Common amino acids AG
Net charge 1
Instability index (II) 8.89
Aliphatic index 54.44
Grand average of hydropathicity (GRAVY) 0.011
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23193596
Title Cn-AMP1: a new promiscuous peptide with potential for microbial infections treatment
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 12255
This work is licensed under a Creative Commons Attribution 4.0 International License.