KK-Temporin-B [G6A]

General Information


DCTPep ID  DCTPep03801

Peptide Name   KK-Temporin-B [G6A]

Sequence  KKLLPIVANLLKSLL

Sequence Length  15

UniProt ID  P79874 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C80H147N19O18

Absent amino acids  CDEFGHMQRTWY

Theoretical pI  10.30

Acidic residues  0

Basic residues  3

Polar residues  2

Molecular weight (Average)  1663.16

Molecular weight (Monoisotopic)  1662.12

Common amino acids  L

Net charge  3

Instability index (II)  5.19

Aliphatic index  208.00

Grand average of hydropathicity (GRAVY)  1.047

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28443279

Title  Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide

Doi Not available

Year  2017

Literature 2

Pubmed ID 30718667

Title  Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

Doi Not available

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  12687

DCTPep is developed by Dr.Zheng's team.