This work is licensed under a Creative Commons Attribution 4.0 International License.
FhHDM-1p2 (14-31) [E3K, I7K, D14K, R15K, E17S]
General Information
DCTPep ID DCTPep03833
Peptide Name FhHDM-1p2 (14-31) [E3K, I7K, D14K, R15K, E17S]
Sequence ITKVITKLLNRLTKILSK
Sequence Length 18
UniProt ID F6KNY7
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | EC50=22.5 ± 0.7μM | PrestoBlue | 30min | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | EC50=29.8 ± 1μM | PrestoBlue | 30min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C96H180N26O24
Absent amino acids ACDEFGHMPQWY
Theoretical pI 11.33
Acidic residues 0
Basic residues 5
Polar residues 5
Molecular weight (Average) 2082.64
Molecular weight (Monoisotopic) 2081.37
Common amino acids KL
Net charge 5
Instability index (II) 5.99
Aliphatic index 167.78
Grand average of hydropathicity (GRAVY) 0.356
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31117348
Title Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics
Doi 10.1021/acsinfecdis.9b00157
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 13426
This work is licensed under a Creative Commons Attribution 4.0 International License.