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Ranatuerin-2Pb
General Information
DCTPep ID DCTPep03848
Peptide Name Ranatuerin-2Pb
Sequence SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT
Sequence Length 34
UniProt ID A9CBH5
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys26<--->Cys32
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C155H272N42O46S2
Absent amino acids EHMPQWY
Theoretical pI 9.70
Acidic residues 1
Basic residues 5
Polar residues 14
Molecular weight (Average) 3524.24
Molecular weight (Monoisotopic) 3521.97
Common amino acids T
Net charge 4
Instability index (II) -13.83
Aliphatic index 111.76
Grand average of hydropathicity (GRAVY) 0.594
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.035, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31242693
Title Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues
Doi Not available
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 13624
This work is licensed under a Creative Commons Attribution 4.0 International License.