AcrAP1, AP1-Z1

General Information


DCTPep ID  DCTPep03851

Peptide Name   AcrAP1, AP1-Z1

Sequence  FLFSLIPHAISGLISAFK

Sequence Length  18

UniProt ID  A0A0A1I6E7 

PubChem CID  102602720 

Origin  Synthetic

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C97H149N21O22

Absent amino acids  CDEMNQRTVWY

Theoretical pI  8.76

Acidic residues  0

Basic residues  2

Polar residues  4

Molecular weight (Average)  1961.38

Molecular weight (Monoisotopic)  1960.12

Common amino acids  FILS

Net charge  2

Instability index (II)  -0.51

Aliphatic index  141.11

Grand average of hydropathicity (GRAVY)  1.411

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31909181

Title  In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide

Doi Not available

Year  2019

Literature 2

Pubmed ID 25332684

Title  Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth modulation effects on human cancer cell lines

Doi Not available

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  13647

DCTPep is developed by Dr.Zheng's team.