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Tat (48-56) + PPF-BBI [5-15]
General Information
DCTPep ID DCTPep03861
Peptide Name Tat (48-56) + PPF-BBI [5-15]
Sequence RKKRRQRRRCWTKSIPPKPC
Sequence Length 20
UniProt ID C3RSZ6
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| H157 | Buccal mucosa squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | 50% viability=100μM | MTT assay | Not available | 1 |
| H460 | Lung large cell carcinoma | 50% viability=100μM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys10<--->Cys20
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H194N44O24S2
Absent amino acids ADEFGHLMNVY
Theoretical pI 12.01
Acidic residues 0
Basic residues 10
Polar residues 4
Molecular weight (Average) 2581.15
Molecular weight (Monoisotopic) 2579.48
Common amino acids R
Net charge 10
Instability index (II) 126.33
Aliphatic index 19.50
Grand average of hydropathicity (GRAVY) -2.190
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5625
Abs 0.1% (=1 g/l) 2.179, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.131, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31337113
Title Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 13836
This work is licensed under a Creative Commons Attribution 4.0 International License.