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Cyclic Tachyplesin-3
General Information
DCTPep ID DCTPep03868
Peptide Name Cyclic Tachyplesin-3
Sequence KWCFRVCYRGICYRKCRG
Sequence Length 18
UniProt ID P14214
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 6PIP
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys16; Cys7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C101H157N33O21S4
Absent amino acids ADEHLMNPQST
Theoretical pI 9.79
Acidic residues 0
Basic residues 6
Polar residues 8
Molecular weight (Average) 2297.81
Molecular weight (Monoisotopic) 2296.11
Common amino acids CR
Net charge 6
Instability index (II) -23.49
Aliphatic index 37.78
Grand average of hydropathicity (GRAVY) -0.478
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 8730
Abs 0.1% (=1 g/l) 3.799, assuming all pairs of Cys residues form cystines
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.690, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31455019
Title Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties
Doi Not available
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 13891
This work is licensed under a Creative Commons Attribution 4.0 International License.