Peptide Libraray

Tritrpticin [P5,9K]

General Information

DCTPep ID DCTPep03899

Peptide Name Tritrpticin [P5,9K]

Sequence VRRFKWWWKFLRR

Sequence Length 13

UniProt ID P51524

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=24μM	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C98H142N30O14

Absent amino acids ACDEGHIMNPQSTY

Theoretical pI 12.48

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1964.4

Molecular weight (Monoisotopic) 1963.13

Common amino acids R

Net charge 6

Instability index (II) 100.61

Aliphatic index 52.31

Grand average of hydropathicity (GRAVY) -1.146

Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 8.400

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17059217

Title Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide

Doi Not available

Year 2006

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 14066