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HLopt2
General Information
DCTPep ID DCTPep03902
Peptide Name HLopt2
Sequence CFQWKRAMRKVR
Sequence Length 12
UniProt ID P02788
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H117N25O14S2
Absent amino acids DEGHILNPSTY
Theoretical pI 11.72
Acidic residues 0
Basic residues 5
Polar residues 1
Molecular weight (Average) 1608.99
Molecular weight (Monoisotopic) 1607.87
Common amino acids R
Net charge 5
Instability index (II) 22.97
Aliphatic index 32.50
Grand average of hydropathicity (GRAVY) -1.042
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.418, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.418, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31513374
Title Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
Doi 10.1021/acschembio.9b00538
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 14104
This work is licensed under a Creative Commons Attribution 4.0 International License.