This work is licensed under a Creative Commons Attribution 4.0 International License.
AGG-KR12-GAGG-KR12-G [Q8,24K; D12,28K]
General Information
DCTPep ID DCTPep03963
Peptide Name AGG-KR12-GAGG-KR12-G [Q8,24K; D12,28K]
Sequence AGGKRIVKRIKKFLRGAGGKRIVKRIKKFLRG
Sequence Length 32
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C166H300N58O33
Absent amino acids CDEHMNPQSTWY
Theoretical pI 12.71
Acidic residues 0
Basic residues 14
Polar residues 6
Molecular weight (Average) 3636.58
Molecular weight (Monoisotopic) 3634.36
Common amino acids K
Net charge 14
Instability index (II) 44.51
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.544
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32153522
Title Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 15043
This work is licensed under a Creative Commons Attribution 4.0 International License.