Peptide Libraray

AMP 22

General Information

DCTPep ID DCTPep03974

Peptide Name AMP 22

Sequence LRKVWRWLRRL

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	80% Killing=100µM	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C75H124N26O12

Absent amino acids ACDEFGHIMNPQSTY

Theoretical pI 12.48

Acidic residues 0

Basic residues 5

Polar residues 0

Molecular weight (Average) 1581.98

Molecular weight (Monoisotopic) 1580.99

Common amino acids R

Net charge 5

Instability index (II) 151.75

Aliphatic index 132.73

Grand average of hydropathicity (GRAVY) -0.736

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 6.953

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31954105

Title Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections

Doi Not available

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 15110