AMP 24

General Information


DCTPep ID  DCTPep03976

Peptide Name   AMP 24

Sequence  LRRLRRLLRRL

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 85% Killing=100µM MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C66H129N29O12

Absent amino acids  ACDEFGHIKMNPQSTVWY

Theoretical pI  12.70

Acidic residues  0

Basic residues  6

Polar residues  0

Molecular weight (Average)  1520.94

Molecular weight (Monoisotopic)  1520.04

Common amino acids  R

Net charge  6

Instability index (II)  217.84

Aliphatic index  177.27

Grand average of hydropathicity (GRAVY)  -0.727

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31954105

Title  Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections

Doi Not available

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  15112

DCTPep is developed by Dr.Zheng's team.