R-DIM-P-LF11

General Information


DCTPep ID  DCTPep04052

Peptide Name   R-DIM-P-LF11

Sequence  FQWQRNIRKVRPRVKRINRQWQF

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C143H227N51O30

Absent amino acids  ACDEGHLMSTY

Theoretical pI  12.70

Acidic residues  0

Basic residues  8

Polar residues  2

Molecular weight (Average)  3140.7

Molecular weight (Monoisotopic)  3138.78

Common amino acids  R

Net charge  8

Instability index (II)  53.46

Aliphatic index  59.13

Grand average of hydropathicity (GRAVY)  -1.574

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 3.502

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Two Novel Anticancer Peptides from Aurein 1.2

Doi 10.1007/s10989-011-9253-0

Year  2011

Literature 2

Pubmed ID 15203252

Title  Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance

Doi Not available

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  16501

DCTPep is developed by Dr.Zheng's team.