Aurein-2.2 (1-14)[V10L, G11K, A12L, G14K]

General Information


DCTPep ID  DCTPep04074

Peptide Name   Aurein-2.2 (1-14)[V10L, G11K, A12L, G14K]

Sequence  GLFDIVKKVLKLLK

Sequence Length  14

UniProt ID  P82389 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H140N18O17

Absent amino acids  ACEHMNPQRSTWY

Theoretical pI  10.00

Acidic residues  1

Basic residues  4

Polar residues  1

Molecular weight (Average)  1614.09

Molecular weight (Monoisotopic)  1613.06

Common amino acids  KL

Net charge  3

Instability index (II)  -14.28

Aliphatic index  180.71

Grand average of hydropathicity (GRAVY)  0.814

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30506920

Title  Simulated Molecular Evolution for Anticancer Peptide Design

Doi Not available

Year  2019

Literature 2

Pubmed ID 32936629

Title  Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides

Doi Not available

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  16801

DCTPep is developed by Dr.Zheng's team.