This work is licensed under a Creative Commons Attribution 4.0 International License.
Aurein-2.2 (1-14)[V10L, G11K, A12L, G14K]
General Information
DCTPep ID DCTPep04074
Peptide Name Aurein-2.2 (1-14)[V10L, G11K, A12L, G14K]
Sequence GLFDIVKKVLKLLK
Sequence Length 14
UniProt ID P82389
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C79H140N18O17
Absent amino acids ACEHMNPQRSTWY
Theoretical pI 10.00
Acidic residues 1
Basic residues 4
Polar residues 1
Molecular weight (Average) 1614.09
Molecular weight (Monoisotopic) 1613.06
Common amino acids KL
Net charge 3
Instability index (II) -14.28
Aliphatic index 180.71
Grand average of hydropathicity (GRAVY) 0.814
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30506920
Title Simulated Molecular Evolution for Anticancer Peptide Design
Doi Not available
Year 2019
Literature 2
Pubmed ID 32936629
Title Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 16801
This work is licensed under a Creative Commons Attribution 4.0 International License.