Peptide Libraray

Defensin-like Protein (35-65), TcPaSK

General Information

DCTPep ID DCTPep04172

Peptide Name Defensin-like Protein (35-65), TcPaSK

Sequence KVNHAACAAHCLLKRKRGGYCNKRRICVCRN

Sequence Length 31

UniProt ID D6X2G2

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys7<--->Cys27; Cys11<--->Cys29

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C146H253N57O36S5

Absent amino acids DEFMPQSTW

Theoretical pI 10.24

Acidic residues 0

Basic residues 11

Polar residues 11

Molecular weight (Average) 3543.28

Molecular weight (Monoisotopic) 3540.83

Common amino acids CR

Net charge 11

Instability index (II) 79.56

Aliphatic index 69.35

Grand average of hydropathicity (GRAVY) -0.545

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1740
Abs 0.1% (=1 g/l) 0.491, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.421, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33499187

Title Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin

Doi Not available

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 18024