This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 (13-32)[I13G,G14I]
General Information
DCTPep ID DCTPep04183
Peptide Name LL-37 (13-32)[I13G,G14I]
Sequence GIKEFKRIVQRIKDFLRNLV
Sequence Length 20
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 50% Cytotoxicity=25.2µM | MTT assay | 18h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C114H194N34O27
Absent amino acids ACHMPSTWY
Theoretical pI 11.00
Acidic residues 2
Basic residues 6
Polar residues 2
Molecular weight (Average) 2473.01
Molecular weight (Monoisotopic) 2471.49
Common amino acids IKR
Net charge 4
Instability index (II) 13.34
Aliphatic index 126.50
Grand average of hydropathicity (GRAVY) -0.225
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34959645
Title Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37
Doi Not available
Year 2021
Literature 2
Pubmed ID 32252021
Title Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 18232
This work is licensed under a Creative Commons Attribution 4.0 International License.