Peptide Libraray

hBD3(1-23)-hBD4(20-28)-hBD3(33-45), H4

General Information

DCTPep ID DCTPep04209

Peptide Name hBD3(1-23)-hBD4(20-28)-hBD3(33-45), H4

Sequence GIINTLQKYYCRVRGGRCAVLSCRSQEYRIGRCSTRGRKCCRRKK

Sequence Length 45

UniProt ID Q8WTQ1

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys11<--->Cys40; Cys18<--->Cys33; Cys23<--->Cys41

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C218H378N82O59S6

Absent amino acids DFHMPW

Theoretical pI 10.65

Acidic residues 1

Basic residues 14

Polar residues 20

Molecular weight (Average) 5284.27

Molecular weight (Monoisotopic) 5280.74

Common amino acids R

Net charge 13

Instability index (II) 49.5

Aliphatic index 58.44

Grand average of hydropathicity (GRAVY) -0.844

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 4845
Abs 0.1% (=1 g/l) 0.917, assuming all pairs of Cys residues form cystines
Ext. coefficient 4470
Abs 0.1% (=1 g/l) 0.846, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34025617

Title A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance

Doi Not available

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 18491