Peptide Libraray

Basic phospholipase A2 BmTX-I (103-117), pBmTxJ

General Information

DCTPep ID DCTPep04260

Peptide Name Basic phospholipase A2 BmTX-I (103-117), pBmTxJ

Sequence YNKKYMKHLKPCKKA

Sequence Length 15

UniProt ID P0C8M1

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C86H142N24O19S2

Absent amino acids DEFGIQRSTVW

Theoretical pI 10.02

Acidic residues 0

Basic residues 7

Polar residues 4

Molecular weight (Average) 1880.34

Molecular weight (Monoisotopic) 1879.03

Common amino acids K

Net charge 7

Instability index (II) 38.7

Aliphatic index 32.67

Grand average of hydropathicity (GRAVY) -1.620

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.585, assuming all pairs of Cys residues form cystines
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.585, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34130109

Title Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria

Doi Not available

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 18752