This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin t-DPH1 [G1W,S4K,A11A,L18K]
General Information
DCTPep ID DCTPep04346
Peptide Name Dermaseptin t-DPH1 [G1W,S4K,A11A,L18K]
Sequence WLWKKIKNVAKAAGKAAKGAL
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C107H178N30O23
Absent amino acids CDEFHMPQRSTY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 3
Molecular weight (Average) 2252.78
Molecular weight (Monoisotopic) 2251.37
Common amino acids AK
Net charge 6
Instability index (II) 6.46
Aliphatic index 98.10
Grand average of hydropathicity (GRAVY) -0.114
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.883
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34943741
Title Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies
Doi Not available
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 18992
This work is licensed under a Creative Commons Attribution 4.0 International License.