Dermaseptin t-DPH1 [G1W,S4K,A11A,L18K]

General Information


DCTPep ID  DCTPep04346

Peptide Name   Dermaseptin t-DPH1 [G1W,S4K,A11A,L18K]

Sequence  WLWKKIKNVAKAAGKAAKGAL

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C107H178N30O23

Absent amino acids  CDEFHMPQRSTY

Theoretical pI  10.70

Acidic residues  0

Basic residues  6

Polar residues  3

Molecular weight (Average)  2252.78

Molecular weight (Monoisotopic)  2251.37

Common amino acids  AK

Net charge  6

Instability index (II)  6.46

Aliphatic index  98.10

Grand average of hydropathicity (GRAVY)  -0.114

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 4.883

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34943741

Title  Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies

Doi Not available

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  18992

DCTPep is developed by Dr.Zheng's team.