This work is licensed under a Creative Commons Attribution 4.0 International License.
BotrAMP14
General Information
DCTPep ID DCTPep04400
Peptide Name BotrAMP14
Sequence KRWKKFFRKVIKFF
Sequence Length 14
UniProt ID U5KJC9
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C100H152N26O15
Absent amino acids ACDEGHLMNPQSTY
Theoretical pI 12.04
Acidic residues 0
Basic residues 7
Polar residues 0
Molecular weight (Average) 1958.47
Molecular weight (Monoisotopic) 1957.19
Common amino acids K
Net charge 7
Instability index (II) 61.36
Aliphatic index 48.57
Grand average of hydropathicity (GRAVY) -0.679
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.808
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32499582
Title Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 19513
This work is licensed under a Creative Commons Attribution 4.0 International License.