Latarcin-3a, Ltc-3a

General Information


DCTPep ID  DCTPep04461

Peptide Name   Latarcin-3a, Ltc-3a

Sequence  SWKSMAKKLKEYMEKLKQRA

Sequence Length  20

UniProt ID  Q1ELU3 

PubChem CID  49777296 

Origin  Animalia

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C111H187N31O29S2

Absent amino acids  CDFGHINPTV

Theoretical pI  10.12

Acidic residues  2

Basic residues  7

Polar residues  3

Molecular weight (Average)  2484.02

Molecular weight (Monoisotopic)  2482.36

Common amino acids  K

Net charge  5

Instability index (II)  32.5

Aliphatic index  49.00

Grand average of hydropathicity (GRAVY)  -1.360

Half Life 
  1.9 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 2.814

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36212827

Title  First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin

Doi 10.3389/fmicb.2022.965621

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  20021

DCTPep is developed by Dr.Zheng's team.