General Information


DCTPep ID  DCTPep04483

Peptide Name  

Sequence  GGGGRGDRGDLPETGGS

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Gly1<--->Ser17

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C59H97N23O26

Absent amino acids  ACFHIKMNQVWY

Theoretical pI  4.56

Acidic residues  3

Basic residues  2

Polar residues  10

Molecular weight (Average)  1544.56

Molecular weight (Monoisotopic)  1543.7

Common amino acids  G

Net charge  -1

Instability index (II)  40.58

Aliphatic index  22.94

Grand average of hydropathicity (GRAVY)  -1.294

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28351594

Title  New potent and selective αvβ3 integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation

Doi 10.1016/j.bmcl.2017.03.035

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  20072

DCTPep is developed by Dr.Zheng's team.