Samoamide A
General Information
DCTPep ID DCTPep04516
Peptide Name Samoamide A
Sequence LVFPIFPP
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Leu1<--->Pro8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C50H72N8O9
Absent amino acids ACDEGHKMNQRSTWY
Theoretical pI 5.52
Acidic residues 0
Basic residues 0
Polar residues 0
Molecular weight (Average) 929.17
Molecular weight (Monoisotopic) 928.54
Common amino acids P
Net charge 0
Instability index (II) 80.97
Aliphatic index 133.75
Grand average of hydropathicity (GRAVY) 1.663
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Synthesis and antitumor activity of cyclic octapeptide, samoamide A, and its derivatives
Doi Not available
Year 2019
Literature 2
Pubmed ID 28055219
Title Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium
Doi Not available
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 20238