Samoamide A

General Information


DCTPep ID  DCTPep04516

Peptide Name   Samoamide A

Sequence  LVFPIFPP

Sequence Length  8

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Leu1<--->Pro8

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C50H72N8O9

Absent amino acids  ACDEGHKMNQRSTWY

Theoretical pI  5.52

Acidic residues  0

Basic residues  0

Polar residues  0

Molecular weight (Average)  929.17

Molecular weight (Monoisotopic)  928.54

Common amino acids  P

Net charge  0

Instability index (II)  80.97

Aliphatic index  133.75

Grand average of hydropathicity (GRAVY)  1.663

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Synthesis and antitumor activity of cyclic octapeptide, samoamide A, and its derivatives

Doi Not available

Year  2019

Literature 2

Pubmed ID 28055219

Title  Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium

Doi Not available

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  20238

DCTPep is developed by Dr.Zheng's team.