This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DCTPep ID DCTPep04524
Peptide Name
Sequence CLLFVY
Sequence Length 6
UniProt ID Not available
PubChem CID 72192490
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Cys1<--->Tyr6
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C38H56N6O8S1
Absent amino acids ADEGHIKMNPQRSTW
Theoretical pI 5.52
Acidic residues 0
Basic residues 0
Polar residues 2
Molecular weight (Average) 756.96
Molecular weight (Monoisotopic) 756.39
Common amino acids L
Net charge 0
Instability index (II) 27.87
Aliphatic index 178.33
Grand average of hydropathicity (GRAVY) 2.633
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.968, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.968, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23796364
Title A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells
Doi Not available
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 20455
This work is licensed under a Creative Commons Attribution 4.0 International License.