Ponericin-W1 (11-25), At1

General Information


DCTPep ID  DCTPep04548

Peptide Name   Ponericin-W1 (11-25), At1

Sequence  KLLPSVVGLFKKKKQ

Sequence Length  15

UniProt ID  P82423 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C82H145N21O18

Absent amino acids  ACDEHIMNRTWY

Theoretical pI  10.60

Acidic residues  0

Basic residues  5

Polar residues  2

Molecular weight (Average)  1713.18

Molecular weight (Monoisotopic)  1712.11

Common amino acids  K

Net charge  5

Instability index (II)  29.46

Aliphatic index  116.67

Grand average of hydropathicity (GRAVY)  -0.213

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36174494

Title  Anticancer effect of rationally designed α-helical amphiphilic peptides

Doi 10.1016/j.colsurfb.2022.112841

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  20545

DCTPep is developed by Dr.Zheng's team.