This work is licensed under a Creative Commons Attribution 4.0 International License.
Ponericin-W1 (11-25) [P4K; S5K; G8K; Q15K], At2
General Information
DCTPep ID DCTPep04549
Peptide Name Ponericin-W1 (11-25) [P4K; S5K; G8K; Q15K], At2
Sequence KLLKKVVKLFKKKKK
Sequence Length 15
UniProt ID P82423
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C91H170N24O16
Absent amino acids ACDEGHIMNPQRSTWY
Theoretical pI 10.90
Acidic residues 0
Basic residues 9
Polar residues 0
Molecular weight (Average) 1856.5
Molecular weight (Monoisotopic) 1855.32
Common amino acids K
Net charge 9
Instability index (II) -25.25
Aliphatic index 116.67
Grand average of hydropathicity (GRAVY) -0.833
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36174494
Title Anticancer effect of rationally designed α-helical amphiphilic peptides
Doi 10.1016/j.colsurfb.2022.112841
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 20546
This work is licensed under a Creative Commons Attribution 4.0 International License.