Lasso peptide Felipeptin A1

General Information


DCTPep ID  DCTPep04565

Peptide Name   Lasso peptide Felipeptin A1

Sequence  GSRGWGFEPGVRCLIWCD

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Bacteria

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  6XTH 

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys8; Cys13<--->Cys17

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C91H132N26O24S2

Absent amino acids  AHKMNQTY

Theoretical pI  6.06

Acidic residues  2

Basic residues  2

Polar residues  7

Molecular weight (Average)  2038.33

Molecular weight (Monoisotopic)  2036.93

Common amino acids  G

Net charge  0

Instability index (II)  48.62

Aliphatic index  59.44

Grand average of hydropathicity (GRAVY)  -0.083

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11125
  Abs 0.1% (=1 g/l) 5.458, assuming all pairs of Cys residues form cystines
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 5.397, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33294793

Title  Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Doi 10.1016/j.isci.2020.101785

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  20590

DCTPep is developed by Dr.Zheng's team.