Peptide Libraray

Lasso peptide Felipeptin A2

General Information

DCTPep ID DCTPep04566

Peptide Name Lasso peptide Felipeptin A2

Sequence GGGGRGYEYNKQCLIFC

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Bacteria

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID 6XTI

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys1<--->Cys8; Cys13<--->Cys17

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C81H121N23O24S2

Absent amino acids ADHMPSTVW

Theoretical pI 8.03

Acidic residues 1

Basic residues 2

Polar residues 10

Molecular weight (Average) 1865.11

Molecular weight (Monoisotopic) 1863.84

Common amino acids G

Net charge 1

Instability index (II) 51.52

Aliphatic index 45.88

Grand average of hydropathicity (GRAVY) -0.435

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 3105
Abs 0.1% (=1 g/l) 1.665, assuming all pairs of Cys residues form cystines
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.598, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33294793

Title Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Doi 10.1016/j.isci.2020.101785

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 20591