Peptide Libraray

D-Pleurocidin KR

General Information

DCTPep ID DCTPep04577

Peptide Name D-Pleurocidin KR

Sequence gwgsffrraahvgrhvgraalthyl

Sequence Length 25

UniProt ID P81941

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=25.3 ± 2.2 μg/ml	XTT assay	120 h	1
Calu-3	Lung adenocarcinoma	IC50=39.1 ± 1.8 μg/ml	XTT assay	120 h	1
A549	Lung adenocarcinoma	IC50=56.5 ± 4.5 μg/ml	XTT assay	120 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293: IC50=36.4 ± 4.3 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral D

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) 2823.22

Molecular weight (Monoisotopic) 2821.49

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33247193

Title A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Doi Not available

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available