D-Pleurocidin KR

General Information


DCTPep ID  DCTPep04577

Peptide Name   D-Pleurocidin KR

Sequence  gwgsffrraahvgrhvgraalthyl

Sequence Length  25

UniProt ID  P81941 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=25.3 ± 2.2 μg/ml XTT assay 120 h 1
Calu-3 Lung adenocarcinoma IC50=39.1 ± 1.8 μg/ml XTT assay 120 h 1
A549 Lung adenocarcinoma IC50=56.5 ± 4.5 μg/ml XTT assay 120 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293: IC50=36.4 ± 4.3 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  D



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  2823.22

Molecular weight (Monoisotopic)  2821.49

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33247193

Title  A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Doi Not available

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.