Peptide Libraray

Pleurocidin VA

General Information

DCTPep ID DCTPep04578

Peptide Name Pleurocidin VA

Sequence GWGSFFKKAAHAGKHAGKAALTHYL

Sequence Length 25

UniProt ID P81941

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50>400 μg/ml	XTT assay	120 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293: IC50~400 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID 6RSG

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C125H184N36O29

Absent amino acids CDEIMNPQRV

Theoretical pI 10.18

Acidic residues 0

Basic residues 7

Polar residues 7

Molecular weight (Average) 2655.06

Molecular weight (Monoisotopic) 2653.4

Common amino acids A

Net charge 7

Instability index (II) 11.76

Aliphatic index 55.20

Grand average of hydropathicity (GRAVY) -0.260

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.633

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33247193

Title A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Doi Not available

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 20614