This work is licensed under a Creative Commons Attribution 4.0 International License.
PR-39
General Information
DCTPep ID DCTPep04661
Peptide Name PR-39
Sequence RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP
Sequence Length 39
UniProt ID PR39_PIG P80054 Q9TR84
PubChem CID 16198954
Origin Sus scrofa
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 4EZO
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Amidation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C229H345N69O41
Absent amino acids ACDEHKMNQSTVW
Theoretical pI 12.60
Acidic residues 0
Basic residues 10
Polar residues 2
Molecular weight (Average) 4720.7
Molecular weight (Monoisotopic) 4717.7
Common amino acids P
Net charge 10
Instability index (II) 118.68
Aliphatic index 30.00
Grand average of hydropathicity (GRAVY) -1.308
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.316
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24755622
Title Antimicrobial and immunomodulatory activities of PR-39 derived peptides
Doi 10.1371/journal.pone.0095939
Year 2014
Literature 2
Pubmed ID 18816382
Title Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon
Year 2008
Literature 3
Pubmed ID 30641213
Title Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity
Doi 10.1016/j.gene.2018.12.065
Year 2019
Literature 4
Pubmed ID 11328767
Title In vitro activity of PR-39, a proline-arginine-rich peptide, against susceptible and multi-drug-resistant Mycobacterium tuberculosis
Year 2001
Literature 5
Pubmed ID 8787891
Title Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP02959
DBAASP ID 7468
This work is licensed under a Creative Commons Attribution 4.0 International License.