This work is licensed under a Creative Commons Attribution 4.0 International License.
BMAP-28
General Information
DCTPep ID DCTPep04662
Peptide Name BMAP-28
Sequence GGLRSLGRKILRAWKKYGPIIVPIIRIG
Sequence Length 28
UniProt ID P54229 B9UKL6 A5PJ96
PubChem CID 16131512
Origin Bos taurus
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Amidation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C147H252N44O31
Absent amino acids CDEFHMNQT
Theoretical pI 12.02
Acidic residues 0
Basic residues 7
Polar residues 7
Molecular weight (Average) 3131.89
Molecular weight (Monoisotopic) 3129.95
Common amino acids I
Net charge 7
Instability index (II) 48.16
Aliphatic index 139.29
Grand average of hydropathicity (GRAVY) 0.232
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.232
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19735644
Title Structure-function study of cathelicidin-derived bovine antimicrobial peptide BMAP-28: design of its cell-selective analogs by amino acid substitutions in the heptad repeat sequences
Doi 10.1016/j.bbamem.2009.08.021
Year 2009
Literature 2
Pubmed ID 16997510
Title Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific
Doi 10.1016/j.vetmic.2006.08.005
Year 2006
Literature 3
Pubmed ID 21655347
Title Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival
Doi 10.1371/journal.pntd.0001141
Year 2011
Literature 4
Pubmed ID 15019203
Title In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs
Doi 10.1016/j.peptides.2003.07.025
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.