Maculatin-1.2

General Information


DCTPep ID  DCTPep04667

Peptide Name   Maculatin-1.2

Sequence  GLFGVLAKVASHVVPAIAEHFQA

Sequence Length  23

UniProt ID  P82067 

PubChem CID  Not available

Origin  Litoria genimaculata

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C111H173N29O28

Absent amino acids  CDMNRTWY

Theoretical pI  6.92

Acidic residues  1

Basic residues  3

Polar residues  3

Molecular weight (Average)  2361.77

Molecular weight (Monoisotopic)  2360.3

Common amino acids  A

Net charge  2

Instability index (II)  14.83

Aliphatic index  123.04

Grand average of hydropathicity (GRAVY)  1.000

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 9620615

Title  The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1

Doi Not available

Year  1998

Literature 2

Pubmed ID 15203252

Title  Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance

Doi 10.1016/j.peptides.2004.03.006

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRAMP ID  DRAMP01365

DBAASP ID  3895

DCTPep is developed by Dr.Zheng's team.