Maculatin-1.2
General Information
DCTPep ID DCTPep04667
Peptide Name Maculatin-1.2
Sequence GLFGVLAKVASHVVPAIAEHFQA
Sequence Length 23
UniProt ID P82067
PubChem CID Not available
Origin Litoria genimaculata
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C111H173N29O28
Absent amino acids CDMNRTWY
Theoretical pI 6.92
Acidic residues 1
Basic residues 3
Polar residues 3
Molecular weight (Average) 2361.77
Molecular weight (Monoisotopic) 2360.3
Common amino acids A
Net charge 2
Instability index (II) 14.83
Aliphatic index 123.04
Grand average of hydropathicity (GRAVY) 1.000
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9620615
Title The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
Doi Not available
Year 1998
Literature 2
Pubmed ID 15203252
Title Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance
Doi 10.1016/j.peptides.2004.03.006
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP01365
DBAASP ID 3895