This work is licensed under a Creative Commons Attribution 4.0 International License.
Nisin A
General Information
DCTPep ID DCTPep04677
Peptide Name Nisin A
Sequence ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK
Sequence Length 34
UniProt ID P13068
PubChem CID Not available
Origin Bacteria
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1WCO
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C143H246N42O45S7
Absent amino acids DEFQRWY
Theoretical pI 8.78
Acidic residues 0
Basic residues 5
Polar residues 18
Molecular weight (Average) 3498.2
Molecular weight (Monoisotopic) 3495.63
Common amino acids CT
Net charge 5
Instability index (II) 27.52
Aliphatic index 71.76
Grand average of hydropathicity (GRAVY) 0.415
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 250
Abs 0.1% (=1 g/l) 0.071, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 8454055
Title Not available
Doi Not available
Year Not available
Literature 2
Pubmed ID 8418850
Title Not available
Doi Not available
Year Not available
Literature 3
Pubmed ID 7689965
Title Not available
Doi Not available
Year Not available
Literature 4
Pubmed ID 5131162
Title Not available
Doi Not available
Year Not available
Literature 5
Pubmed ID 3141403
Title Not available
Doi Not available
Year Not available
Literature 6
Pubmed ID 29767501
Title Not available
Doi Not available
Year Not available
Literature 7
Pubmed ID 2493449
Title Not available
Doi Not available
Year Not available
Literature 8
Pubmed ID 1905517
Title Not available
Doi Not available
Year Not available
Literature 9
Pubmed ID 1765078
Title Not available
Doi Not available
Year Not available
Literature 10
Pubmed ID 16559344
Title Not available
Doi Not available
Year Not available
Literature 11
Pubmed ID 1575686
Title Not available
Doi Not available
Year Not available
Literature 12
Pubmed ID 15232069
Title Not available
Doi Not available
Year Not available
Literature 13
Pubmed ID 1482192
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP00036
This work is licensed under a Creative Commons Attribution 4.0 International License.