This work is licensed under a Creative Commons Attribution 4.0 International License.
Plantaricin A
General Information
DCTPep ID DCTPep04684
Peptide Name Plantaricin A
Sequence KSSAYSLQMGATAIKQVKKLFKKWGW
Sequence Length 26
PubChem CID Not available
Origin Lactobacillus plantarum
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1YTR
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H222N36O34S1
Absent amino acids CDEHNPR
Theoretical pI 10.40
Acidic residues 0
Basic residues 6
Polar residues 7
Molecular weight (Average) 2985.58
Molecular weight (Monoisotopic) 2983.65
Common amino acids K
Net charge 6
Instability index (II) 19.84
Aliphatic index 67.69
Grand average of hydropathicity (GRAVY) -0.423
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 12490
Abs 0.1% (=1 g/l) 4.183
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9603847
Title Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A
Doi 10.1128/AEM.64.6.2269-2272.1998
Year 1998
Literature 2
Pubmed ID 8245827
Title Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides
Doi 10.1099/00221287-139-9-1973
Year 1993
Literature 3
Pubmed ID 18957441
Title Not available
Doi Not available
Year Not available
Literature 4
Pubmed ID 15805109
Title Structure and mode of action of the membrane-permeabilizing antimicrobial peptide pheromone plantaricin A
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.