This work is licensed under a Creative Commons Attribution 4.0 International License.
Cn-AMP2
General Information
DCTPep ID DCTPep04685
Peptide Name Cn-AMP2
Sequence TESYFVFSVGM
Sequence Length 11
UniProt ID P86706
PubChem CID Not available
Origin Treponema succinifaciens
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 1321N1 | Astrocytoma | IC50 =1.25mM | MTS assay | 72h | 1 |
| U87MG | Astrocytoma | IC50=1.85mM | MTS assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Amidation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C59H83N11O18S1
Absent amino acids ACDHIKLNPQRW
Theoretical pI 4.00
Acidic residues 1
Basic residues 0
Polar residues 5
Molecular weight (Average) 1266.43
Molecular weight (Monoisotopic) 1265.56
Common amino acids FSV
Net charge -1
Instability index (II) 36.39
Aliphatic index 52.73
Grand average of hydropathicity (GRAVY) 0.764
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.177
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25234689
Title Cn-AMP2 from green coconut water is an anionic anticancer peptide
Doi 10.1002/psc.2684
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.