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Gomesin [PYA1E]
General Information
DCTPep ID DCTPep04688
Peptide Name Gomesin [PYA1E]
Sequence ECRRLCYKQRCVTYCRGR
Sequence Length 18
UniProt ID P82358
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1KFP
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Amidation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C93H157N35O25S4
Absent amino acids ADFHIMNPSW
Theoretical pI 9.58
Acidic residues 1
Basic residues 6
Polar residues 8
Molecular weight (Average) 2293.73
Molecular weight (Monoisotopic) 2292.1
Common amino acids R
Net charge 5
Instability index (II) 65.21
Aliphatic index 37.78
Grand average of hydropathicity (GRAVY) -1.061
Half Life
1 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 3230
Abs 0.1% (=1 g/l) 1.408, assuming all pairs of Cys residues form cystines
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.299, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30068931
Title Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation
Doi 10.1038/s41598-018-29826-4
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.