Nisin Z
General Information
DCTPep ID DCTPep04695
Peptide Name Nisin Z
Sequence ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Sequence Length 34
UniProt ID LANZ_LACLL P29559
PubChem CID Not available
Origin Lactococcus lactis
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1WCO
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C141H245N41O46S7
Absent amino acids DEFQRWY
Theoretical pI 8.78
Acidic residues 0
Basic residues 4
Polar residues 19
Molecular weight (Average) 3475.16
Molecular weight (Monoisotopic) 3472.61
Common amino acids CT
Net charge 4
Instability index (II) 17.08
Aliphatic index 71.76
Grand average of hydropathicity (GRAVY) 0.406
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 250
Abs 0.1% (=1 g/l) 0.072, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 8439149
Title Not available
Doi Not available
Year Not available
Literature 2
Pubmed ID 7626780
Title Not available
Doi Not available
Year Not available
Literature 3
Pubmed ID 1935953
Title Not available
Doi Not available
Year Not available
Literature 4
Pubmed ID 15361862
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP00037