This work is licensed under a Creative Commons Attribution 4.0 International License.
Viscotoxin A3
General Information
DCTPep ID DCTPep04696
Peptide Name Viscotoxin A3
Sequence KSCCPNTTGRNIYNACRLTGAPRPTCAKLSGCKIISGSTCPSDYPK
Sequence Length 46
UniProt ID P01538 THN3_VISAL
PubChem CID Not available
Origin Viscum album
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C201H334N62O64S6
Absent amino acids EFHMQVW
Theoretical pI 9.30
Acidic residues 1
Basic residues 7
Polar residues 25
Molecular weight (Average) 4835.6
Molecular weight (Monoisotopic) 4832.31
Common amino acids C
Net charge 6
Instability index (II) 49.56
Aliphatic index 48.91
Grand average of hydropathicity (GRAVY) -0.463
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 3355
Abs 0.1% (=1 g/l) 0.694, assuming all pairs of Cys residues form cystines
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 0.616, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 5719166
Title Not available
Doi Not available
Year Not available
Literature 2
Pubmed ID 4941626
Title Not available
Doi Not available
Year Not available
Literature 3
Pubmed ID 18957441
Title Not available
Doi Not available
Year Not available
Literature 4
Pubmed ID 1710983
Title Not available
Doi Not available
Year Not available
Literature 5
Pubmed ID 10947973
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP00954
CancerPPD ID 4441
This work is licensed under a Creative Commons Attribution 4.0 International License.