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Viscotoxin B
General Information
DCTPep ID DCTPep04703
Peptide Name Viscotoxin B
Sequence KSCCPNTTGRNIYNTCRLGGGSRERCASLSGCKIISASTCPSDYPK
Sequence Length 46
UniProt ID P01536 THNB_VISAL P08943 P84186
PubChem CID Not available
Origin Viscum album
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys8<--->Cys25
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C197H328N64O67S6
Absent amino acids FHMQVW
Theoretical pI 9.13
Acidic residues 2
Basic residues 7
Polar residues 27
Molecular weight (Average) 4857.52
Molecular weight (Monoisotopic) 4854.26
Common amino acids S
Net charge 5
Instability index (II) 46.52
Aliphatic index 46.74
Grand average of hydropathicity (GRAVY) -0.550
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 3355
Abs 0.1% (=1 g/l) 0.691, assuming all pairs of Cys residues form cystines
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 0.613, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18957441
Title Not available
Doi Not available
Year Not available
Literature 2
Pubmed ID 1710983
Title Not available
Doi Not available
Year Not available
Literature 3
Pubmed ID 12733989
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP00955
CancerPPD ID 4446
This work is licensed under a Creative Commons Attribution 4.0 International License.