L-amino-acid oxidase L2
General Information
DCTPep ID DCTPep04755
Peptide Name L-amino-acid oxidase L2
Sequence ADDKNPLEECFCEDDDYCEG
Sequence Length 20
UniProt ID P0DI90
PubChem CID Not available
Origin Daboia russelii
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H132N22O41S3
Absent amino acids HIMQRSTVW
Theoretical pI 3.51
Acidic residues 9
Basic residues 1
Polar residues 6
Molecular weight (Average) 2310.37
Molecular weight (Monoisotopic) 2308.81
Common amino acids D
Net charge -8
Instability index (II) 47.47
Aliphatic index 24.50
Grand average of hydropathicity (GRAVY) -1.315
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 0.699, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.645, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18384385
Title Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs
Doi 10.1111/j.1742-4658.2008.06362.x
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP02466