L-amino-acid oxidase L2

General Information


DCTPep ID  DCTPep04755

Peptide Name   L-amino-acid oxidase L2

Sequence  ADDKNPLEECFCEDDDYCEG

Sequence Length  20

UniProt ID  P0DI90 

PubChem CID  Not available

Origin  Daboia russelii

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C93H132N22O41S3

Absent amino acids  HIMQRSTVW

Theoretical pI  3.51

Acidic residues  9

Basic residues  1

Polar residues  6

Molecular weight (Average)  2310.37

Molecular weight (Monoisotopic)  2308.81

Common amino acids  D

Net charge  -8

Instability index (II)  47.47

Aliphatic index  24.50

Grand average of hydropathicity (GRAVY)  -1.315

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1615
  Abs 0.1% (=1 g/l) 0.699, assuming all pairs of Cys residues form cystines
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.645, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18384385

Title  Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs

Doi 10.1111/j.1742-4658.2008.06362.x

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRAMP ID  DRAMP02466

DCTPep is developed by Dr.Zheng's team.