L-amino-acid oxidase ACTX-8

General Information


DCTPep ID  DCTPep04756

Peptide Name   L-amino-acid oxidase ACTX-8

Sequence  ADDRNPLEEFRENNYEEFL

Sequence Length  19

UniProt ID  P0DI85 

PubChem CID  Not available

Origin  Deinagkistrodon acutus

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C104H150N28O38

Absent amino acids  CGHIKMQSTVW

Theoretical pI  4.00

Acidic residues  7

Basic residues  2

Polar residues  4

Molecular weight (Average)  2400.5

Molecular weight (Monoisotopic)  2399.07

Common amino acids  E

Net charge  -5

Instability index (II)  36.36

Aliphatic index  46.32

Grand average of hydropathicity (GRAVY)  -1.679

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.621

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17275856

Title  ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells

Doi 10.1016/j.lfs.2006.12.024

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRAMP ID  DRAMP02488

DCTPep is developed by Dr.Zheng's team.