This work is licensed under a Creative Commons Attribution 4.0 International License.
L-amino-acid oxidase ACTX-8
General Information
DCTPep ID DCTPep04756
Peptide Name L-amino-acid oxidase ACTX-8
Sequence ADDRNPLEEFRENNYEEFL
Sequence Length 19
UniProt ID P0DI85
PubChem CID Not available
Origin Deinagkistrodon acutus
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H150N28O38
Absent amino acids CGHIKMQSTVW
Theoretical pI 4.00
Acidic residues 7
Basic residues 2
Polar residues 4
Molecular weight (Average) 2400.5
Molecular weight (Monoisotopic) 2399.07
Common amino acids E
Net charge -5
Instability index (II) 36.36
Aliphatic index 46.32
Grand average of hydropathicity (GRAVY) -1.679
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.621
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17275856
Title ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DRAMP ID DRAMP02488
This work is licensed under a Creative Commons Attribution 4.0 International License.