Aurein-3.1.2

General Information


DCTPep ID  DCTPep04760

Peptide Name   Aurein-3.1.2

Sequence  FDIVKKIAGHIAGSI

Sequence Length  15

UniProt ID  P69021 

PubChem CID  Not available

Origin  Litoria aurea

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C73H121N19O19

Absent amino acids  CELMNPQRTWY

Theoretical pI  8.60

Acidic residues  1

Basic residues  3

Polar residues  3

Molecular weight (Average)  1568.88

Molecular weight (Monoisotopic)  1567.91

Common amino acids  I

Net charge  2

Instability index (II)  33.61

Aliphatic index  136.67

Grand average of hydropathicity (GRAVY)  0.833

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 10951191

Title  The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2

Doi 10.1046/j.1432-1327.2000.01536.x

Year  2000

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRAMP ID  DRAMP01616

DCTPep is developed by Dr.Zheng's team.