This work is licensed under a Creative Commons Attribution 4.0 International License.
Hexastatin-1
General Information
DCTPep ID DCTPep04823
Peptide Name Hexastatin-1
Sequence ATPFIECSGARGTCHYFAN
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens (α6 CIV)
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H129N25O27S2
Absent amino acids DKLMQVW
Theoretical pI 6.77
Acidic residues 1
Basic residues 2
Polar residues 9
Molecular weight (Average) 2045.27
Molecular weight (Monoisotopic) 2043.89
Common amino acids A
Net charge 1
Instability index (II) 92.74
Aliphatic index 36.32
Grand average of hydropathicity (GRAVY) -0.005
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 0.790, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.729, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18780781
Title A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.