cyclic decapeptide

General Information


DCTPep ID  DCTPep04840

Peptide Name   cyclic decapeptide

Sequence  CTTHWGFTLC

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys10

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C52H73N13O14S2

Absent amino acids  ADEIKMNPQRSVY

Theoretical pI  6.72

Acidic residues  0

Basic residues  1

Polar residues  6

Molecular weight (Average)  1168.35

Molecular weight (Monoisotopic)  1167.48

Common amino acids  T

Net charge  1

Instability index (II)  28.35

Aliphatic index  39.00

Grand average of hydropathicity (GRAVY)  0.500

Half Life 
  1.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5625
  Abs 0.1% (=1 g/l) 4.814, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 4.707, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17121909

Title  How molecular imaging is speeding up antiangiogenic drug development

Doi 10.1158/1535-7163.MCT-06-0395

Year  2006

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.