Properdistatin

General Information


DCTPep ID  DCTPep04881

Peptide Name   Properdistatin

Sequence  GPWEPCSVTCSKGTRTRRR

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Homo sapiens (Properdin)

Type  Synthetic peptide

Classification

  

Cancer targeted peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  CD36

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C89H149N33O27S2

Absent amino acids  ADFHILMNQY

Theoretical pI  10.72

Acidic residues  1

Basic residues  5

Polar residues  9

Molecular weight (Average)  2177.49

Molecular weight (Monoisotopic)  2176.07

Common amino acids  R

Net charge  4

Instability index (II)  61.02

Aliphatic index  15.26

Grand average of hydropathicity (GRAVY)  -1.305

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5625
  Abs 0.1% (=1 g/l) 2.583, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.526, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18780781

Title  A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells

Doi 10.1073/pnas.0803241105

Year  2008

Literature 2

Pubmed ID 21470139

Title  Anti-angiogenic peptides for cancer therapeutics

Doi 10.2174/138920111796117300

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.