Aurein 2.2

General Information


DCTPep ID  DCTPep04938

Peptide Name   Aurein 2.2

Sequence  MAFLKKSLFLVLFLGLVSLSICEKEKRQNEEDEDENEAANHEEGSEEKRGLFDIVKKVVGALGSLGKRNDLE

Sequence Length  72

UniProt ID  Q5K0E6 

PubChem CID  Not available

Origin  Litoria aurea

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C355H578N96O115S2

Absent amino acids  PTWY

Theoretical pI  4.84

Acidic residues  16

Basic residues  12

Polar residues  16

Molecular weight (Average)  8095.19

Molecular weight (Monoisotopic)  8090.18

Common amino acids  EL

Net charge  -4

Instability index (II)  44.22

Aliphatic index  96.11

Grand average of hydropathicity (GRAVY)  -0.461

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 15203252

Title  Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance

Doi 10.1016/j.peptides.2004.03.006

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.